Description

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Non-alcoholic fatty liver disease (NAFLD) refers to a heterogeneous condition with an extensive range of clinical presentations and disease severity. People who suffer from this disease are observed to consume little or no alcohol, and have excessive fat stored in their liver cells. Damage to the liver under this condition is caused by the generation of oxidative metabolites and by the translocation of gut-derived endotoxin. These processes result in cellular injury and stimulation of the inflammatory responses facilitated by a range of molecules. The injury develops with impairment in tissue regeneration and extracellular matrix turnover which results in causing cirrhosis and fibrogenesis. Some of the major risk factors for this disease are obesity, insulin resistance and diabetes. This book explores all the important translational and clinical researches on non-alcoholic fatty liver disease in the modern day. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of the subject.