Description

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We have all been hypoxic. Fetal tolerance for intrauterine hypoxia arises from evolutionarily conserved physiological mechanisms, the antecedents of which can be learned from diving mammals or species at high altitudes. Understanding fetal hypoxia leads to understanding the huge physiological shifts of neonatal transition and the dangers of perinatal hypoxia.

This comprehensive volume of topical review articles by expert authors addresses the origins of hypoxia tolerance, the impact of oxygen on circulatory transition at birth, and the biochemistry of hypoxia in the pulmonary circuit, as well as the classification, diagnosis, and clinical management of hypoxic respiratory failure and persistent pulmonary hypertension in the term neonate.

The goal of Hypoxic Respiratory Failure in the Newborn is to connect our understanding of hypoxia from animals in extreme environments, with how the human fetus handles its hypoxic environment; and why the human newborn suddenly cannot. The book will educate health care professionals on how to care for newborns with hypoxic respiratory failure, including the use of up-to-date diagnostic tools and therapies. It also highlights areas of controversy and ongoing research in hypoxic respiratory failure and pulmonary hypertension of the newborn, including challenging case studies.

Key Features

Explores evolutionary context and comparative physiology of hypoxia tolerance in the fetus and neonate, from basic research to clinical scenarios

Provides guidance to trainees, physicians, and allied health professionals engaged in NICU care; pediatricians, cardiologists, pulmonologists, anesthesiologists, neonatologists, and physiologists to effectively manage infants in hypoxic respiratory failure

Includes case scenarios emphasizing current diagnostic and therapeutic controversies and algorithmic approaches to decipher difficult clinical cases

About the Author

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EditorDr Shyamala Dakshinamurti is a neonatologist and biomedical researcher, Professor of Pediatrics and Physiology at the University of Manitoba, Canada, and member of the Biology of Breathing theme, Children's Hospital Research Institute of Manitoba.Section EditorsDr Steven H. Abman is Professor of Pediatrics and Director of the Pediatric Heart Lung Center at the University of Colorado Anschutz School of Medicine and the Children's Hospital Colorado, USA.Dr Po-Yin Cheung is a neonatologist of the Northern Alberta Neonatal Program of Alberta Health Services and Professor in the Departments of Pediatrics, Pharmacology and Surgery at the University of Alberta, Canada.Dr Satyan Lakshminrusimha is a neonatologist and the Dennis and Nancy Marks Chair and Professor of Pediatrics at the University of California at Davis, Sacramento, USA.Dr Patrick McNamara is a staff neonatologist and Director of the Division of Neonatology at the University of Iowa Stead Family Children's Hospital and Professor of Pediatrics and Internal Medicine, University of Iowa, USA.Dr William K. Milsom is a comparative physiologist and Emeritus Professor of Zoology at the University of British Columbia, Canada.